New perspectives in glioblastoma antiangiogenic therapy
Glioblastoma (GB) is highly vascularised tumour, known to exhibit enhanced infiltrative potential.One of the characteristics of glioblastoma is microvascular proliferation surrounding necrotic areas, as a response to a hypoxic environment, which in turn increases the expression of angiogenic factors and their signalling pathways (RAS/RAF/ERK/MAPK p